MicroRNA-146a, a therapeutic target and biomarker for peripartum cardiomyopathy
نویسندگان
چکیده
1. Unit of Molecular Biology and Genetic Engineering, GIGA, University of Liège, Liège, Belgium 2. Department of Cardiology and Angiology, Medical School Hannover, Germany 3. Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medical School Hannover, Germany 4. Laboratory of Biology of Tumor and Development, GIGA-Cancer, University of Liège, Liège, Belgium 5. Department of Ophthalmology, University Hospital (CHU), LiègeBelgium 6. Laboratoire de Biologie Cellulaire et tissulaire, GIGA, University of Liege, Belgium 7. Hatter Institute for Cardiovascular Research in Africa & IIDMM, Department of Medicine, University of Cape Town, Cape Town, South Africa.
منابع مشابه
MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.
Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL), the underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression in ECs, which attenuated angiogenesis through downregulation of N...
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تاریخ انتشار 2013